# Acute myeloid leukaemia research and treatment advances > Live situation record from CLSTR: https://clstr.news/situations/acute-myeloid-leukaemia-research-and-treatment-advances > Updated: 2026-08-10T17:36:56.000Z. Sources: 2. Developments: 2. Research into acute myeloid leukaemia (AML) has focused on identifying new therapeutic targets and improving clinical decision-making. Initial studies demonstrated that combining FLT3 kinase inhibition with Hedgehog pathway inhibition produced a synergistic anti-cancer effect, which selectively reduced the transport of specific proteins into extracellular vesicles. Subsequent developments have expanded on drug combination strategies and diagnostic modeling. Researchers identified that a three-drug combination of inobrodib, venetoclax, and gilteritinib was more effective at targeting resilient leukemia stem cells in laboratory models than individual or dual treatments. Additionally, the development of the HSCT-64 machine-learning model utilizes transcriptomic data to assist clinicians in determining the necessity of hematopoietic stem cell transplantation for pediatric AML patients. ## Timeline ### 2026-08-10: Advances in AML treatment target leukemia stem cells and transplant decisions New medical advancements in AML treatment include a three-drug combination to target leukemia stem cells and a machine-learning model to personalize stem cell transplant decisions for pediatric patients. 2 sources. https://clstr.news/cluster/advances-in-aml-treatment-target-leukemia-stem-cells-and-transplant-decisions ### 2026-07-22: Extracellular Vesicle Advances in AML Therapy and Human Milk Research Recent research shows combined FLT3 and Hedgehog inhibition alters AML extracellular vesicles, while a review outlines therapeutic prospects and challenges of human‑milk‑derived vesicles. 2 sources. https://clstr.news/cluster/extracellular-vesicle-advances-in-aml-therapy-and-human-milk-research --- Cite as: Acute myeloid leukaemia research and treatment advances. CLSTR, https://clstr.news/situations/acute-myeloid-leukaemia-research-and-treatment-advances