# Advancements and clinical approaches to menopause therapy > Live situation record from CLSTR: https://clstr.news/situations/advancements-and-clinical-approaches-to-menopause-therapy > Updated: 2026-09-04T08:51:17.000Z. Sources: 6. Developments: 2. Recent developments in menopause management highlight both scientific advancements in targeted treatments and the clinical necessity for personalized care. Researchers at the University of São Paulo have developed a targeted hormone replacement strategy that activates only the estrogen receptor beta (ERβ). In studies involving rats, this method addressed metabolic issues such as insulin resistance and lipid profiles without stimulating reproductive tissues like the uterus or breasts. This approach aims to mitigate risks for individuals predisposed to hormone-sensitive tumors. Complementing these scientific developments, medical experts emphasize that hormone replacement therapy must be tailored to the individual. Practitioners note that treatment decisions should account for age, symptom severity, and specific contraindications, such as a history of blood clots, liver disease, or certain cancers. ## Timeline ### 2026-09-04: Medical experts advise personalized hormone therapy for menopause Experts warn that hormone therapy for menopause symptoms must be personalized, noting that certain medical histories like cancer or blood clots may make the treatment unsuitable for some women. 2 sources. https://clstr.news/cluster/medical-experts-advise-personalized-hormone-therapy-for-menopause ### 2026-08-27: University of São Paulo researchers develop targeted menopause hormone therapy USP researchers have developed a targeted hormone replacement strategy that activates only the estrogen receptor beta, improving metabolic health without stimulating hormone-sensitive reproductive tissues. 4 sources. https://clstr.news/cluster/university-of-so-paulo-researchers-develop-targeted-menopause-hormone-therapy --- Cite as: Advancements and clinical approaches to menopause therapy. CLSTR, https://clstr.news/situations/advancements-and-clinical-approaches-to-menopause-therapy