# Advancements in colorectal and liver cancer immunotherapy > Live situation record from CLSTR: https://clstr.news/situations/advancements-in-colorectal-and-liver-cancer-immunotherapy > Updated: 2026-09-06T19:05:40.000Z. Sources: 4. Developments: 2. Medical researchers are making progress in immunotherapy for colorectal and liver cancers. In Singapore, scientists at Nanyang Technological University developed peptide microdrops that use small interfering RNA (siRNA) to deliver gene-silencing molecules. This method aims to interrupt proteins used by colorectal cancer cells to evade the immune system, showing a reduction in tumor growth in mouse studies. Simultaneously, researchers from CONICET, Universidad Austral, and other institutions have identified the SMYD2 protein as a therapeutic target for hepatocellular carcinoma (HCC). The study indicates that inhibiting SMYD2 reduces tumor growth and modifies the tumor microenvironment to improve immune response. Lead researcher Guillermo Mazzolini noted that combining SMYD2 inhibition with anti-PD-1 immunotherapy produced a greater antitumor response than either treatment alone, offering potential for patients resistant to standard immunotherapies. ## Timeline ### 2026-09-06: CONICET scientists identify protein to improve liver cancer treatment CONICET scientists identified the SMYD2 protein as a potential target to improve liver cancer treatment by enhancing immunotherapy effectiveness and reducing tumor growth. 2 sources. https://clstr.news/cluster/conicet-scientists-identify-protein-to-improve-liver-cancer-treatment ### 2026-09-06: Researchers advance immunotherapy for colorectal and liver cancers New research highlights breakthroughs in cancer treatment, including peptide microdrops for colorectal cancer and SMYD2 protein inhibition to enhance immunotherapy for liver cancer. 2 sources. https://clstr.news/cluster/researchers-advance-immunotherapy-for-colorectal-and-liver-cancers --- Cite as: Advancements in colorectal and liver cancer immunotherapy. CLSTR, https://clstr.news/situations/advancements-in-colorectal-and-liver-cancer-immunotherapy