# Advancements in gene therapy control technologies > Live situation record from CLSTR: https://clstr.news/situations/advancements-in-gene-therapy-control-technologies > Updated: 2026-08-31T07:44:00.000Z. Sources: 5. Developments: 2. Researchers have reported advancements in gene therapy technology focused on improving the precision and delivery of gene expression control. At Dongguk University in South Korea, a team led by Professor Jongpil Kim developed an electromagnetic field (EMF)-responsive gene switch. Utilizing the promoter of the Lgr4 gene, this tool allows for non-invasive, reversible, and precise control over gene expression. Testing in mouse models has shown potential for reversing aging markers and modeling Alzheimer’s disease. Concurrently, scientists at Stanford Medicine developed an ultracompact gene activation tool named TIGRa. Designed to overcome the size limitations of bulky CRISPR-based systems, TIGRa is small enough to be packaged into a single adeno-associated virus. In mouse models of retinal degeneration, the tool was used to activate protective genes in retinal ganglion cells, helping subjects retain partial vision compared to untreated subjects. This development suggests potential applications for treating glaucoma and other retinal degenerative conditions. ## Timeline ### 2026-08-31: Stanford Medicine researchers develop ultracompact TIGRa gene activation tool Stanford Medicine researchers developed TIGRa, an ultracompact gene activation tool that fits into viral vectors to more efficiently trigger protective genes for treating diseases like glaucoma. 3 sources. https://clstr.news/cluster/stanford-medicine-researchers-develop-ultracompact-tigra-gene-activation-tool ### 2026-08-28: Researchers develop new tools for precise gene therapy control Scientists have developed new gene therapy tools: an EMF-responsive switch for non-invasive control and TIGRa, an ultracompact tool for efficient gene activation in viral vectors. 2 sources. https://clstr.news/cluster/researchers-develop-new-tools-for-precise-gene-therapy-control --- Cite as: Advancements in gene therapy control technologies. CLSTR, https://clstr.news/situations/advancements-in-gene-therapy-control-technologies