# Alzheimer's disease progression research > Live situation record from CLSTR: https://clstr.news/situations/alzheimers-disease-progression-research > Updated: 2026-08-21T06:00:00.000Z. Sources: 2. Developments: 2. Research published in Nature Metabolism has identified a potential link between glucosamine supplement use and the acceleration of Alzheimer’s disease. A retrospective study by University of Florida researchers, analyzing health records from 2012 to 2024, found that older adults with mild cognitive impairment who used the supplement had a 25% higher likelihood of progressing to dementia. Additionally, among those already diagnosed with Alzheimer’s, glucosamine use was associated with a 25% increase in mortality risk. Further research has expanded the investigation into external factors affecting disease progression. Microbiologists at the University of Louisville have explored the connection between oral infections and Alzheimer’s, identifying the bacterium Porphyromonas gingivalis—associated with periodontal disease—in the brains of deceased patients. Laboratory experiments on mice indicated that oral infection with this bacterium can lead to brain colonization and an increase in beta-amyloid proteins. ## Timeline ### 2026-08-21: Alzheimer's research links glucosamine and oral bacteria to disease progression New research links Alzheimer's progression to glucosamine supplement use in some patients and identifies oral bacteria, Porphyromonas gingivalis, as a potential factor in brain colonization. 2 sources. https://clstr.news/cluster/alzheimers-research-links-glucosamine-and-oral-bacteria-to-disease-progression ### 2026-08-04: Glucosamine supplement associated with accelerated Alzheimer's progression University of Florida research links glucosamine use to a 25% higher risk of dementia progression and increased mortality in Alzheimer's patients, urging medical consultation. 2 sources. https://clstr.news/cluster/glucosamine-supplement-associated-with-accelerated-alzheimers-progression --- Cite as: Alzheimer's disease progression research. CLSTR, https://clstr.news/situations/alzheimers-disease-progression-research