# Alzheimer's disease research advancements > Live situation record from CLSTR: https://clstr.news/situations/alzheimers-disease-research-advancements > Updated: 2026-09-10T04:55:03.000Z. Sources: 29. Developments: 4. Researchers are developing new methods to track and potentially reverse the effects of Alzheimer’s disease. At the University of South Carolina, scientists have developed a nanoparticle-based treatment called Nano-ERASER to convert astrocytes into functioning neurons. Other diagnostic frontiers include high-density EEG, FDA-authorized blood tests, and the ‘early-onset Alzheimer’s disease signature’ developed by Harvard Medical School to measure gray matter atrophy. Recent advancements have introduced diverse therapeutic approaches. Researchers at the University of Coimbra are utilizing artificial intelligence to identify mechanisms that block the movement of toxic proteins. At the Leuven Brain Institute, studies on transcranial direct current stimulation (tDCS) have shown that applying low-intensity electrical impulses to the trigeminal nerve can increase signaling between neurons in the hippocampus by 20%, with human participants demonstrating improved short-term memory. In Italy, scientists from Università Cattolica del Sacro Cuore and associated institutions have developed a nasal spray using nanovesicles derived from the amniotic membrane. In experimental models, this spray reached the hippocampus, counteracting neuroinflammation and protecting neuronal function and synapses. This treatment may potentially prevent memory deficits or combat existing cognitive decline. Despite these breakthroughs, clinicians face ongoing challenges in predictive care. While blood biomarkers are increasingly accessible, neurologists emphasize the difficulty in accurately predicting the speed at which individuals with biological markers will progress to dementia. This remains a critical concern as dementia cases in Italy are projected to rise from 1.43 million to 2.2 million by 2050. ## Claims - The study was conducted by scientists from Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli Irccs, and the E. Menni Research Center. (corroborated by 3 sources) - An intranasal spray containing nanovesicles from amniotic membrane cells may combat Alzheimer's disease. (corroborated by 3 sources) - The spray reached the hippocampus in an Alzheimer's animal model. (corroborated by 3 sources) - The treatment counteracts neuroinflammation and protects neuron function. (corroborated by 3 sources) - The spray showed positive results on human neurons in vitro. (corroborated by 3 sources) - The nanovesicles can both prevent the onset of memory deficits and counteract existing cognitive decline. (corroborated by 3 sources) ## Timeline ### 2026-09-10: Alzheimer's research: Nasal spray shows promise in protecting neurons Italian scientists have developed a nasal spray using amniotic membrane nanovesicles that may protect neurons and memory in Alzheimer's models. Experts also emphasize the move toward predictive medicine. 11 sources. https://clstr.news/cluster/alzheimers-research-intranasal-spray-shows-promise-in-protecting-neurons ### 2026-09-08: Neuroscience research advances Alzheimer's treatments and memory enhancement Researchers are exploring new neurological interventions, including AI-driven Alzheimer's research at the University of Coimbra and facial electrical stimulation to enhance memory via the hippocampus. 6 sources. https://clstr.news/cluster/neuroscience-research-advances-alzheimers-treatments-and-memory-enhancement ### 2026-08-26: Alzheimer’s disease research advances early detection and treatment New research highlights advancements in Alzheimer’s disease, including early detection via blood tests, EEG, and MRI, alongside potential treatments involving lactate infusion and nanoparticle therapy. 10 sources. https://clstr.news/cluster/alzheimers-research-advances-with-neuroregeneration-and-predictive-biomarkers ### 2026-08-26: Medical researchers report breakthroughs in cerebral palsy diagnosis and Alzheimer's treatment Medical researchers report breakthroughs in early cerebral palsy diagnosis for children under age 4 and a new Nano-ERASER technology that restores cognitive function in Alzheimer's disease mouse models. 2 sources. https://clstr.news/cluster/medical-researchers-report-breakthroughs-in-cerebral-palsy-diagnosis-and-alzheimers-treatment --- Cite as: Alzheimer's disease research advancements. CLSTR, https://clstr.news/situations/alzheimers-disease-research-advancements