# Bestzyme automated brazzein production development > Live situation record from CLSTR: https://clstr.news/situations/bestzyme-automated-brazzein-production-development > Updated: 2026-09-25T04:46:00.000Z. Sources: 6. Developments: 2. Bestzyme, a synthetic biology subsidiary of GenScript Biotech, has completed the world’s first automated production line for the sweet protein brazzein at its facility in Jinan, China. The 5,000-square-meter facility utilizes an integrated “fermentation — purification — freeze-drying” process to produce the protein, which is derived from the West African Oubli fruit. The company’s flagship product, branded as Mellia, is thousands of times sweeter than sucrose and is designed to be blended with other sweeteners like stevia to replicate the taste of sugar without calories. Once fully operational, the facility is expected to have an annual capacity of over 100 tons, providing sweetness equivalent to approximately 300,000 tons of sucrose. Bestzyme has already begun commercial expansion in the United States, where the product is being used in a sugar-free sparkling water brand following an FDA “No Questions Letter” regarding its GRAS status in May 2025. In China, the company has submitted food additive applications to the National Health Commission and intends to double its production capacity within the next two years. ## Timeline ### 2026-09-25: Bestzyme completes automated brazzein production line in China Bestzyme Biotech has launched a dedicated automated production line in China for brazzein, a high-intensity sweet protein, aiming for an annual capacity of over 100 tons to serve the global sugar-alternative 시장 2 sources. https://clstr.news/cluster/bestzyme-completes-automated-brazzein-production-line-in-china ### 2026-09-22: Bestzyme launches world's first automated sweet protein production line Bestzyme has launched the world’s first automated smart production line for sweet proteins in Jinan, aiming to provide a high-capacity, zero-calorie alternative to sugar for the food industry. 4 sources. https://clstr.news/cluster/bestzyme-launches-worlds-first-automated-sweet-protein-production-line --- Cite as: Bestzyme automated brazzein production development. CLSTR, https://clstr.news/situations/bestzyme-automated-brazzein-production-development