# Clinical development of diabetic foot infection treatments > Live situation record from CLSTR: https://clstr.news/situations/clinical-development-of-diabetic-foot-infection-treatments > Updated: 2026-08-25T22:45:52.000Z. Sources: 7. Developments: 2. Biotechnology companies are advancing clinical trials for topical gel treatments targeting diabetic foot infections and ulcers. In Australia, Recce Pharmaceuticals has received ethics committee approval to expand its Phase 3 clinical trial for RECCE 327 Topical Gel (R327G). The expanded protocol includes a randomized, active-controlled study arm involving 208 patients to compare the gel against four physician-selected antibiotics. The trial also incorporates wound imaging via digital photography to provide objective measurements. Concurrently, US-based Lakewood-Amedex Biotherapeutics is preparing for a Phase 2a clinical trial of Nu-3, a topical Bisphosphocin gel. This treatment is designed to combat infectious diseases and antibiotic-resistant bacterial strains by physically disrupting bacterial membranes. Lakewood-Amedex was recently named a ‘Featured Company’ by B2i Digital, a designation intended to help the firm present its clinical programs and scientific milestones to a broader network of retail and institutional market participants. ## Timeline ### 2026-08-25: Lakewood-Amedex Biotherapeutics named B2i Digital Featured Company Lakewood-Amedex Biotherapeutics has joined B2i Digital as a Featured Company to highlight its upcoming Phase 2a trial of Nu-3, a topical gel for treating infected diabetic foot ulcers. 4 sources. https://clstr.news/cluster/lakewood-amedex-biotherapeutics-to-begin-phase-2a-trial-for-nu-3-gel ### 2026-08-19: Recce Pharmaceuticals expands Phase 3 trial for diabetic foot infection gel Recce Pharmaceuticals has secured approval to expand its Phase 3 clinical trial for RECCE 327 Topical Gel, aiming to treat Diabetic Foot Infections through head-to-head comparisons with existing antibiotics. 3 sources. https://clstr.news/cluster/recce-pharmaceuticals-expands-phase-3-trial-for-diabetic-foot-infection-gel --- Cite as: Clinical development of diabetic foot infection treatments. CLSTR, https://clstr.news/situations/clinical-development-of-diabetic-foot-infection-treatments