# Creatine neuroprotection study in animal models > Developing situation record from CLSTR: https://clstr.news/situations/creatine-neuroprotection-study-in-animal-models > Updated: 2026-10-18T19:13:27.000Z. Sources: 9. Developments: 2. Researchers at the University of Seville have published findings in the journal ‘Brain, Behavior, and Immunity’ suggesting that creatine supplementation may protect the brain from damage caused by chronic gut inflammation, such as colitis. In animal studies involving rodents, daily creatine doses helped restore creatine levels in the hippocampus, a brain region vital for learning and memory. The supplementation was observed to reduce neuronal cell damage and normalize neuronal excitability. The research noted sex-based differences, with male subjects exhibiting more severe neurological impairments and structural damage, while female subjects showed different patterns of calcium channel regulation. While the study suggests creatine could be a ‘powerful, complementary and preventive strategy’ for managing neurological effects of inflammatory bowel diseases, scientists emphasize that these results are based on preclinical animal models and cannot yet be generalized to humans. ## Timeline ### 2026-10-18: Creatine may protect brain cells from inflammation, study suggests A study on rodents suggests that creatine supplementation may protect brain cells in the hippocampus from damage caused by intestinal inflammation. 5 sources. https://clstr.news/cluster/creatine-may-protect-brain-cells-from-inflammation-study-suggests ### 2026-10-13: Creatine may protect brain from gut inflammation, study finds A study by the University of Seville suggests creatine may protect the hippocampus from inflammation-induced damage linked to chronic gut diseases, though results are currently limited to animal models. 4 sources. https://clstr.news/cluster/creatine-supplementation-may-protect-hippocampus-from-colitis-induced-inflammation --- Cite as: Creatine neuroprotection study in animal models. CLSTR, https://clstr.news/situations/creatine-neuroprotection-study-in-animal-models