# Endometriosis and migraine clinical connection > Live situation record from CLSTR: https://clstr.news/situations/endometriosis-and-migraine-clinical-connection > Updated: 2026-10-25T09:31:01.000Z. Sources: 4. Developments: 2. Medical research has identified a significant link between endometriosis and migraines, noting that women with endometriosis are more than twice as likely to suffer from migraines. Studies suggest that pain intensity in endometriosis does not always correlate with the physical extent of lesions, potentially due to complex interactions between hormones, immune cells, and nerve fibers. A meta-analysis of 35 studies involving over 13 million women highlighted a diagnostic gap, where up to 90 percent of women suffering from both disorders were missed in short-term medical records because the conditions are often managed by different specialists. Researchers suggest the two conditions may share a common pain pathway. This discovery has prompted suggestions for new treatment approaches, such as utilizing migraine medications that block the calcitonin gene-related peptide (CGRP) to address endometriosis-related pain. ## Timeline ### 2026-10-25: Research links increased migraine risk in women with endometriosis A study of 13 million women shows that endometriosis patients are twice as likely to experience migraines, suggesting a shared pain pathway and potential new treatment avenues. 2 sources. https://clstr.news/cluster/research-links-increased-migraine-risk-in-women-with-endometriosis ### 2026-10-22: Endometriosis research highlights pain persistence and migraine links Medical research indicates that hormonal treatments may not fully resolve endometriosis pain due to complex immune and nerve interactions, noting a high prevalence of co-occurring migraines. 2 sources. https://clstr.news/cluster/endometriosis-research-highlights-pain-persistence-and-migraine-links --- Cite as: Endometriosis and migraine clinical connection. CLSTR, https://clstr.news/situations/endometriosis-and-migraine-clinical-connection