# GLP-1 medication use and reproductive health > Developing situation record from CLSTR: https://clstr.news/situations/glp-1-medication-use-and-reproductive-health > Updated: 2026-10-23T09:21:06.000Z. Sources: 5. Developments: 2. Medical discussions have highlighted a potential link between GLP-1 medications and improved fertility outcomes for certain women, specifically those managing obesity and polycystic ovary syndrome (PCOS). While anecdotal reports suggest successful conception following treatment, medical reviews indicate that the drugs may improve reproductive health by reducing insulin resistance and weight, potentially leading to better ovulation rates. However, experts emphasize that GLP-1s are not standard fertility treatments. The American College of Obstetricians and Gynecologists has released the first clinical guidelines regarding these medications, advising pregnant women to forgo their use due to insufficient data on fetal effects. Healthcare providers are encouraged to recommend that patients discontinue GLP-1 use one to two months before attempting to conceive. Regarding breastfeeding, guidelines suggest use might be acceptable after a baby’s first month, though the impact on nutrient absorption and breast milk remains unknown. ## Timeline ### 2026-10-23: American OB-GYNs issue first guidelines for GLP-1 use during pregnancy The American College of Obstetricians and Gynecologists has issued new guidelines advising pregnant women to avoid GLP-1 drugs due to insufficient data on fetal impact. 3 sources. https://clstr.news/cluster/american-ob-gyns-issue-first-guidelines-for-glp-1-use-during-pregnancy ### 2026-10-14: GLP-1 medications may improve fertility outcomes for some women Medical reviews and anecdotal evidence suggest GLP-1 medications may improve fertility in women with PCOS and obesity by reducing inflammation and insulin resistance, though experts advise caution. 2 sources. https://clstr.news/cluster/glp-1-medications-may-improve-fertility-outcomes-for-some-women --- Cite as: GLP-1 medication use and reproductive health. CLSTR, https://clstr.news/situations/glp-1-medication-use-and-reproductive-health