# Health impacts of artificial sweetener consumption > Live situation record from CLSTR: https://clstr.news/situations/health-impacts-of-artificial-sweetener-consumption > Updated: 2026-10-22T12:17:22.000Z. Sources: 4. Developments: 2. Research studies have identified various health risks associated with the long-term consumption of artificial sweeteners. An eight-year study by the University of São Paulo involving over 12,000 Brazilian adults found a link between high sweetener intake and accelerated cognitive decline. Participants consuming the highest amounts showed a decline in memory, information processing speed, and verbal fluency approximately 63 percent faster than low-consumption groups, a rate equivalent to an additional 1.6 years of cognitive aging. Complementary research from the University of Chile, published in Frontiers in Nutrition, suggests that sweeteners like sucralose and stevia may negatively impact metabolism. Using mouse models, researchers observed that metabolic consequences, such as insulin resistance, might be transmissible to offspring and subsequent generations through epigenetic shifts. The study also noted potential changes in the intestinal microbiome. ## Timeline ### 2026-10-22: Study links artificial sweeteners to metabolic changes and generational risks Research from the University of Chile suggests artificial sweeteners like sucralose may cause metabolic issues and insulin resistance that could be passed down to future generations. 2 sources. https://clstr.news/cluster/study-links-artificial-sweeteners-to-metabolic-changes-and-generational-risks ### 2026-10-22: Artificial sweeteners linked to accelerated cognitive decline A study of over 12,000 adults suggests that high consumption of artificial sweeteners is linked to a 63 percent faster decline in cognitive functions, equivalent to 1.6 years of additional brain aging. 2 sources. https://clstr.news/cluster/artificial-sweeteners-linked-to-accelerated-cognitive-decline --- Cite as: Health impacts of artificial sweetener consumption. CLSTR, https://clstr.news/situations/health-impacts-of-artificial-sweetener-consumption