# Introduction of GPSMult genetic heart disease test

> Live situation record from CLSTR: https://clstr.news/situations/introduction-of-gpsmult-genetic-heart-disease-test
> Updated: 2026-10-25T06:01:12.000Z. Sources: 4. Developments: 2.

Researchers, including those from Lund University and the Broad Institute of MIT and Harvard, have developed a new genetic test called GPSMult. This blood test evaluates approximately one million genetic risk variants to identify individuals with a high innate risk of heart attack or coronary artery disease, even when traditional risk factors like smoking or high cholesterol are absent.

A study of over 25,000 participants indicated that the top fifth of individuals with the highest polygenic risk face danger levels comparable to those with a history of stroke or type 2 diabetes. Professor Olle Melander noted that such individuals often remain undetected by standard medical screenings.

The clinical tool is intended for use by physicians in primary care settings, specifically targeting patients in a ‘middle zone’ who lack obvious risk factors. The test is expected to be available in healthcare settings around the turn of the year or early next year, pending a health economic analysis to confirm its cost-effectiveness. Early detection via this method may allow doctors to recommend lifestyle adjustments or lifelong medication to mitigate risks.

## Timeline

### 2026-10-25: New genetic test identifies high heart attack risk

A new clinical genetic test will be available next year to identify individuals with a high congenital risk of heart attack, helping doctors manage preventative care for middle-risk patients.

2 sources. https://clstr.news/cluster/new-genetic-test-identifies-high-heart-attack-risk

### 2026-10-21: New genetic test identifies hidden heart disease risk

A new genetic test called GPSMult can identify individuals with high innate heart disease risk who lack traditional symptoms, potentially becoming available in healthcare by early next year.

2 sources. https://clstr.news/cluster/new-genetic-test-identifies-hidden-heart-disease-risk

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Cite as: Introduction of GPSMult genetic heart disease test. CLSTR, https://clstr.news/situations/introduction-of-gpsmult-genetic-heart-disease-test
