# Medical regulation of aesthetic substances in Brazil > Live situation record from CLSTR: https://clstr.news/situations/medical-regulation-of-aesthetic-substances-in-brazil > Updated: 2026-10-12T01:40:14.000Z. Sources: 6. Developments: 2. Medical authorities and scientific entities in Brazil are moving to restrict various substances used for aesthetic purposes due to safety concerns. In September 2026, the Federal Council of Medicine (CFM) banned the use of PMMA (polymethylmethacrylate) as an injectable dermal filler for both aesthetic and restorative purposes. The ban, enacted via Resolution CFM No. 2.461/2026, was prompted by evidence of serious complications such as granuloma formation, infections, necrosis, and impaired renal function. The only exception is the treatment of lipodystrophy in patients living with HIV/AIDS, which must be conducted through accredited high-complexity units. By October 2026, twelve national and international medical organizations, including the Brazilian Society of Endocrinology and Metabology, issued the Rio de Janeiro Letter. This document urges the National Health Surveillance Agency (Anvisa) to implement a total ban on compounded hormonal implants, frequently referred to as “beauty chips.” Signatories warn that these implants lack sufficient clinical evidence to prove safety or efficacy for their marketed uses, such as weight loss or libido enhancement. ## Timeline ### 2026-10-12: Medical societies urge ban on compounded hormonal implants in Brazil Twelve medical entities are urging Anvisa to ban compounded hormonal implants, known as “beauty chips,” citing a lack of clinical safety data and risks associated with aesthetic use. 2 sources. https://clstr.news/cluster/medical-societies-urge-ban-on-compounded-hormonal-implants-in-brazil ### 2026-09-14: Brazil bans PMMA as injectable dermal filler Brazil's Federal Council of Medicine has banned PMMA as an injectable filler for aesthetic and restorative uses due to risks of severe complications like infection, necrosis, and renal impairment. 4 sources. https://clstr.news/cluster/brazil-bans-pmma-as-injectable-dermal-filler --- Cite as: Medical regulation of aesthetic substances in Brazil. CLSTR, https://clstr.news/situations/medical-regulation-of-aesthetic-substances-in-brazil