# Nicotine product use and metabolic disease risks

> Live situation record from CLSTR: https://clstr.news/situations/nicotine-product-use-and-metabolic-disease-risks
> Updated: 2026-08-21T02:04:12.000Z. Sources: 4. Developments: 2.

Recent scientific studies have identified correlations between various nicotine delivery methods and increased risks of metabolic disorders.

An international study involving approximately 2.8 million people found that exclusive e-cigarette users face a 34 percent higher risk of developing prediabetes compared to non-users. The research, published in ‘Internal and Emergency Medicine’, also noted a 37 percent increase in insulin resistance among e-cigarette users and a 26 percent increased risk for those combining e-cigarettes with traditional cigarettes.

In a separate 4.8-year tracking study of 29,000 non-diabetic workers, researchers found that users of heated tobacco products face a 1.61 times higher risk of developing type 2 diabetes compared to non-smokers. Those using both heated tobacco and traditional cigarettes showed a 1.76 times higher risk, while traditional cigarette smokers showed a 1.53 times higher risk.

## Timeline

### 2026-08-21: Heated tobacco use linked to 1.6x higher diabetes risk

Research from the National Institute for Health Crisis Management shows heated tobacco users have a 1.61 times higher risk of developing type 2 diabetes than non-smokers.

2 sources. https://clstr.news/cluster/heated-tobacco-use-linked-to-16x-higher-diabetes-risk

### 2026-08-14: E-cigarette use linked to increased prediabetes risk

A study of 2.8 million people suggests e-cigarette use is linked to a 34 percent higher risk of prediabetes and a 37 percent increase in insulin resistance.

2 sources. https://clstr.news/cluster/e-cigarette-use-linked-to-increased-prediabetes-risk

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Cite as: Nicotine product use and metabolic disease risks. CLSTR, https://clstr.news/situations/nicotine-product-use-and-metabolic-disease-risks