# Pfizer lorlatinib long‑term lung cancer results > Live situation record from CLSTR: https://clstr.news/situations/pfizer-lorlatinib-longterm-lung-cancer-results > Updated: 2026-08-07T17:42:44.000Z. Sources: 4. Developments: 2. Pfizer presented a seven‑year update of the phase III CROWN trial at the 2026 American Society of Clinical Oncology (ASCO) meeting. The trial compared lorlatinib with crizotinib as first‑line therapy for patients with advanced ALK‑positive non‑small cell lung cancer. Results showed a 94 % reduction in the risk of intracranial disease progression, with 83 % of lorlatinib‑treated patients remaining free of brain progression after seven years. More than half of the participants (55 %) were still free of overall disease progression at the same time point, and median progression‑free survival had not yet been reached. The safety profile remained consistent with earlier data, with no new safety signals identified. Pfizer’s medical lead for oncology in Latin America highlighted the durability of benefit during simultaneous seminars in Mexico City, São Paulo and Buenos Aires. ## Timeline ### 2026-08-07: Pfizer's lorlatinib cuts intracranial progression risk 94% in ALK‑positive lung cancer Pfizer’s seven‑year CROWN trial update shows lorlatinib reduces intracranial progression risk by 94% and yields 83% brain‑progression‑free survival at seven years in ALK‑positive lung cancer, with safety stable 2 sources. https://clstr.news/cluster/pfizers-lorlatinib-cuts-intracranial-progression-risk-94-in-alkpositive-lung-cancer ### 2026-08-05: Pfizer's lorlatinib cuts intracranial progression risk by 94% in ALK‑positive lung cancer Pfizer’s lorlatinib cut intracranial progression risk by 94% in ALK‑positive lung cancer; 7‑year CROWN trial shows lasting benefit and stable safety profile. 2 sources. https://clstr.news/cluster/pfizers-lorlatinib-cuts-intracranial-progression-risk-by-94-in-alkpositive-lung-cancer --- Cite as: Pfizer lorlatinib long‑term lung cancer results. CLSTR, https://clstr.news/situations/pfizer-lorlatinib-longterm-lung-cancer-results