# Regulatory efforts to reduce animal testing in drug research > Live situation record from CLSTR: https://clstr.news/situations/regulatory-efforts-to-reduce-animal-testing-in-drug-research > Updated: 2026-10-04T12:09:44.000Z. Sources: 5. Developments: 2. The International Coalition of Medicines Regulatory Authorities (ICMRA) issued a joint statement calling for the accelerated development and implementation of alternatives to animal testing in human medicine development. The coalition aims to replace animal experimentation across all stages of a medicine’s life cycle whenever scientifically possible, emphasizing the need for international collaboration and the acceptance of validated non-animal methods by regulatory authorities. Following this, the European Medicines Agency (EMA) announced its support for the ICMRA statement. Proposed alternatives include the use of cells, tissues, three-dimensional and microphysiological systems, computer modeling, artificial intelligence, and increased human data. The EMA noted that in the European Union, animal use for pharmaceutical regulatory testing decreased by approximately half between 2015 and 2023. The initiative seeks to harmonize requirements across countries to ensure validated alternative methods are accepted during development and authorization stages. ## Timeline ### 2026-10-04: EMA supports reducing animal testing in drug development The EMA supports a global initiative to gradually replace animal testing in drug development with alternatives like AI, computer modeling, and cell-based systems to ensure safety and efficiency. 3 sources. https://clstr.news/cluster/ema-supports-reducing-animal-testing-in-drug-development ### 2026-10-02: ICMRA calls for alternatives to animal testing in drug development The ICMRA has issued a joint statement urging the development and implementation of non-animal alternatives for human medicine testing throughout all stages of the drug life cycle. 2 sources. https://clstr.news/cluster/icmra-calls-for-alternatives-to-animal-testing-in-drug-development --- Cite as: Regulatory efforts to reduce animal testing in drug research. CLSTR, https://clstr.news/situations/regulatory-efforts-to-reduce-animal-testing-in-drug-research