# Research into dementia neuropathology and genetics > Live situation record from CLSTR: https://clstr.news/situations/research-into-dementia-neuropathology-and-genetics > Updated: 2026-09-24T10:21:45.000Z. Sources: 4. Developments: 2. Scientific research has advanced the understanding of the biological and genetic drivers behind various forms of dementia. An international study led by the Université de Montréal identified that brain tissue loss in dementia with Lewy bodies preferentially affects specific posterior regions, including the parietal, temporal, and occipital lobes. This cortical thinning was linked to the transcription of genes related to synaptic communication and mitochondrial function. Subsequent research has expanded on the neuropathological and genetic architecture of dementia-related proteinopathies. One study found that vascular brain injury has a minimal impact on cognitive decline compared to other concurrent neuropathologies in Alzheimer disease patients. Additionally, large-scale whole-genome sequencing has identified genetic associations with specific proteins such as Aβ, tau, α-synuclein, and TDP-43, validating known risk alleles like GBA and TMEM106B while suggesting new alleles for further study. ## Timeline ### 2026-09-24: Research identifies genetic and neuropathological drivers of dementia New research explores the genetic and neuropathological drivers of dementia, identifying specific proteinopathy-linked alleles and the varying impacts of concurrent brain injuries on cognitive decline. 2 sources. https://clstr.news/cluster/research-identifies-genetic-and-neuropathological-drivers-of-dementia ### 2026-08-26: Brain regions found more vulnerable to dementia with Lewy bodies Researchers have discovered that dementia with Lewy bodies preferentially causes brain atrophy in specific posterior regions linked to mitochondrial and synaptic gene activity. 2 sources. https://clstr.news/cluster/brain-regions-found-more-vulnerable-to-dementia-with-lewy-bodies --- Cite as: Research into dementia neuropathology and genetics. CLSTR, https://clstr.news/situations/research-into-dementia-neuropathology-and-genetics