# Research on acute endophthalmitis treatment protocols

> Live situation record from CLSTR: https://clstr.news/situations/research-on-acute-endophthalmitis-treatment-protocols
> Updated: 2026-08-16T22:50:55.000Z. Sources: 3. Developments: 2.

Clinical research in the United Kingdom is challenging established treatment protocols for acute bacterial endophthalmitis. A phase 2 feasibility trial, known as the EVIAN trial, conducted by researchers from University College London and Moorfields Eye Hospital, evaluated the effectiveness of early vitrectomy compared to the conventional regimen of repeated intraocular antibiotic injections.

The study, which involved 63 patients across 21 UK hospitals, found that patients receiving early vitrectomy within 48–96 hours of diagnosis showed significantly better outcomes. At six months, those in the surgical group achieved a median visual acuity gain of 40 letters, more than three times the median gain of 13 letters observed in the antibiotic-first group.

Further research has indicated that topical antibiotics may not reduce the incidence of endophthalmitis following intravitreal injections, suggesting that prevention should instead prioritize rigorous antiseptic techniques using povidone-iodine.

## Claims

- Early vitrectomy shows promise for treating bacterial endophthalmitis. (single source)
- Patients receiving early vitrectomy experienced more than three times the median improvement in vision compared to those receiving repeated intravitreal antibiotics. (single source)
- The EVIAN trial enrolled 63 patients from 21 hospitals across the UK. (single source)
- Topical antibiotics do not reduce the incidence of endophthalmitis following intravitreal injections. (single source)
- In a 5-year study at The Ottawa Hospital, 44% of eyes with acute retinal necrosis developed retinal detachment. (single source)

## Timeline

### 2026-08-16: Ophthalmology research suggests early vitrectomy improves endophthalmitis outcomes

New clinical research suggests early vitrectomy may improve vision outcomes for bacterial endophthalmitis, while other studies question the efficacy of topical antibiotics in preventing eye infections.

3 sources. https://clstr.news/cluster/ophthalmology-research-suggests-early-vitrectomy-improves-endophthalmitis-outcomes

### 2026-08-02: UK Study Finds Early Vitrectomy Improves Vision in Acute Endophthalmitis

A UK trial of 63 patients shows early vitrectomy (within 48‑96 h) yields a median 40‑letter vision gain versus 13 letters with conventional antibiotics for acute endophthalmitis.

3 sources. https://clstr.news/cluster/uk-study-finds-early-vitrectomy-improves-vision-in-acute-endophthalmitis

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Cite as: Research on acute endophthalmitis treatment protocols. CLSTR, https://clstr.news/situations/research-on-acute-endophthalmitis-treatment-protocols