# Retatrutide clinical trials for sleep apnea

> Developing situation record from CLSTR: https://clstr.news/situations/retatrutide-clinical-trials-for-sleep-apnea
> Updated: 2026-10-31T14:00:17.000Z. Sources: 8. Developments: 2.

Clinical trials, specifically the TRIUMPH-1-OSA and TRIUMPH-2-OSA Phase 3 studies, have indicated that the investigational weight-loss medication retatrutide may significantly reduce the severity of obstructive sleep apnea (OSA).

Results published in the New England Journal of Medicine showed that participants receiving once-weekly injections of retatrutide experienced a greater reduction in the apnea-hypopnea index (AHI) compared to a placebo group. In participants without type 2 diabetes, AHI reductions ranged from approximately 23 to 34 events per hour, while those with type 2 diabetes saw reductions between 19 and 25 events per hour. Additionally, participants experienced weight loss between 12% and 22%.

Broader research into sleep apnea highlights the condition’s interaction with diabetes, noting that sleep apnea may increase risks for cardiovascular dysfunction and chronic kidney disease. The potential for oral medications like retatrutide to serve as alternatives to CPAP masks is being explored as part of new therapeutic approaches.

## Claims

- Obstructive sleep apnea can affect individuals who do not fit the classic risk profile. (reported by 2 sources)
- Snoring and daytime fatigue are potential signs of obstructive sleep apnea. (reported by 2 sources)
- Two Phase 3 studies of Retatrutide showed a reduction in breathing pauses. (reported by 1 source)
- Sleep apnea increases the risk of microvascular complications in patients with diabetes. (reported by 1 source)
- Nighttime hypoxia levels may predict cardiovascular events in diabetics more effectively than the apnea-hypopnea index. (reported by 1 source)

## Timeline

### 2026-10-31: Sleep apnea research highlights new therapies and health risks

Medical experts and studies highlight the risks of undiagnosed sleep apnea, its link to diabetes complications, and emerging treatments like Retatrutide.

4 sources. https://clstr.news/cluster/sleep-apnea-research-highlights-new-therapies-and-health-risks

### 2026-10-25: Retatrutide reduces sleep apnea severity in clinical trials

Clinical trials for the investigational drug retatrutide show significant reductions in sleep apnea severity and substantial weight loss in adults with obesity.

4 sources. https://clstr.news/cluster/retatrutide-reduces-sleep-apnea-severity-in-clinical-trials

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Cite as: Retatrutide clinical trials for sleep apnea. CLSTR, https://clstr.news/situations/retatrutide-clinical-trials-for-sleep-apnea