# San Francisco 49ers injury crisis

> Live situation record from CLSTR: https://clstr.news/situations/san-francisco-49ers-injury-crisis
> Updated: 2026-09-29T00:15:46.000Z. Sources: 21. Developments: 2.

The San Francisco 49ers continue to navigate a significant wave of injuries following their 36-30 victory over the Arizona Cardinals. Star pass rusher Nick Bosa is expected to miss multiple weeks due to a calf injury sustained during a warmup. While the team has not yet moved to place him on injured reserve, his absence creates a notable void in the pass rush.

The roster has been further depleted by season-ending injuries to defensive tackle Alfred Collins and receiver Ricky Pearsall. Other key players are also managing setbacks, including wide receiver Mike Evans with rib issues and left tackle Trent Williams with a neck injury.

To address the lack of depth, the 49ers have signed veteran defensive end Matthew Judon to the practice squad. Additionally, trade rumors have emerged linking the team to Arizona Cardinals edge rusher Josh Sweat as a potential move to bolster the defense before the trade deadline.

## Timeline

### 2026-09-29: San Francisco 49ers face injury crisis as Nick Bosa sidelined

The San Francisco 49ers face mounting injury concerns, including a multi-week absence for defensive end Nick Bosa, prompting potential trade interest in edge rusher Josh Sweat.

6 sources. https://clstr.news/cluster/san-francisco-49ers-face-major-injury-setbacks-with-nick-bosa-sidelined

### 2026-09-25: Nick Bosa expected to miss multiple weeks with calf injury

San Francisco 49ers star Nick Bosa is expected to miss several weeks with a calf injury, adding to a mounting list of defensive line absences ahead of their game against the Arizona Cardinals.

19 sources. https://clstr.news/cluster/nick-bosa-expected-to-miss-weeks-with-calf-injury

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Cite as: San Francisco 49ers injury crisis. CLSTR, https://clstr.news/situations/san-francisco-49ers-injury-crisis