# Scientific reviews of mRNA technology safety > Developing situation record from CLSTR: https://clstr.news/situations/scientific-reviews-of-mrna-technology-safety > Updated: 2026-10-31T08:32:14.000Z. Sources: 6. Developments: 2. Scientific literature reviews published in late October 2026 have evaluated the safety and toxicological profiles of modified mRNA technology. A review in the Journal of Toxicology examined research from 2020 to 2026, identifying unresolved questions regarding biodistribution, lipid nanoparticles, and the duration of spike protein production. The study also noted concerns regarding myocarditis, neurological and reproductive events, and potential long-term biological consequences. Concurrently, researchers examined the persistence of vaccine-related molecules, referencing findings where mRNA was detected in blood plasma 28 days after injection and spike protein fragments remained for up to 187 days. The research also highlighted potential toxicological concerns regarding lipid nanoparticles, noting their ability to enter the bloodstream and affect organs such as the liver and spleen, with reports suggesting they may disrupt lymphocyte maturation. ## Timeline ### 2026-10-31: Researchers examine mRNA vaccine persistence and lipid nanoparticle effects New scientific reviews examine the long-term presence of mRNA vaccine components and the potential toxicological impact of lipid nanoparticles on organs like the liver and spleen. 4 sources. https://clstr.news/cluster/researchers-examine-mrna-vaccine-persistence-and-lipid-nanoparticle-effects ### 2026-10-30: Journal of Toxicology review identifies safety gaps in mRNA technology A review in the Journal of Toxicology examining six years of mRNA research identifies ongoing safety concerns regarding biodistribution, myocarditis, and long-term biological effects. 2 sources. https://clstr.news/cluster/journal-of-toxicology-review-identifies-safety-gaps-in-mrna-technology --- Cite as: Scientific reviews of mRNA technology safety. CLSTR, https://clstr.news/situations/scientific-reviews-of-mrna-technology-safety