# Tadalafil use and glaucoma risk association > Live situation record from CLSTR: https://clstr.news/situations/tadalafil-use-and-glaucoma-risk-association > Updated: 2026-09-07T08:27:37.000Z. Sources: 7. Developments: 2. Research involving approximately 74,000 men has identified a statistical link between the use of tadalafil and an increased risk of glaucoma. One study indicates that users face a 22% higher risk of developing glaucoma, with a 33% increased risk for primary open-angle glaucoma and a 32% higher incidence of ocular hypertension. While the relative risk is significant, researchers noted that the absolute difference remains small, with diagnosis rates appearing in just under 4% of users compared to approximately 3% of control groups. The findings, published in the British Journal of Ophthalmology, do not prove a direct cause-and-effect relationship, but researchers suggest that men using the medication for lower urinary tract symptoms may require closer ophthalmic monitoring. In Brazil, health data showed a massive increase in tadalafil consumption between 2024 and 2025, rising from three million to nearly 65 million units. Experts have noted concerns regarding off-label use among younger populations as a gym supplement or pre-workout. ## Timeline ### 2026-09-07: Tadalafil linked to 22% higher glaucoma risk in large study A study in the British Journal of Ophthalmology found that men taking daily tadalafil for urinary symptoms face a 22% higher relative risk of developing glaucoma. 3 sources. https://clstr.news/cluster/tadalafil-linked-to-22-higher-glaucoma-risk-in-large-study ### 2026-08-19: Tadalafil use linked to increased glaucoma and vision loss risk A study of over 70,000 men links tadalafil use to a 22% increased risk of glaucoma and higher rates of ocular hypertension, prompting medical warnings regarding vision loss. 4 sources. https://clstr.news/cluster/tadalafil-use-linked-to-increased-glaucoma-and-vision-loss-risk --- Cite as: Tadalafil use and glaucoma risk association. CLSTR, https://clstr.news/situations/tadalafil-use-and-glaucoma-risk-association