# US cancer mortality rate trends

> Live situation record from CLSTR: https://clstr.news/situations/us-cancer-mortality-rate-trends
> Updated: 2026-09-28T01:29:38.000Z. Sources: 8. Developments: 2.

The American Association for Cancer Research (AACR) released its 16th annual Cancer Progress Report, documenting a 35% reduction in cancer deaths in the United States between 1991 and 2024. This decline accounts for approximately 4.8 million fewer deaths.

According to the report, the primary drivers of this progress include lower smoking rates, advancements in early diagnosis and prevention, and more effective therapeutic options. The five-year relative survival rate for patients with distant cancer disease has more than doubled, increasing from 17% in the mid-1990s to 36% during the 2016–2022 period.

Future oncology developments are expected to involve artificial intelligence, liquid biopsies, cancer vaccines, and new RNA-based therapeutic approaches.

## Timeline

### 2026-09-28: US cancer mortality rates fell by 35% since 1991

The AACR Cancer Progress Report shows US cancer deaths fell by 35% between 1991 and 2024, driven by better prevention, diagnosis, and emerging technologies like AI and RNA therapies.

2 sources. https://clstr.news/cluster/us-cancer-mortality-rates-fell-by-35-since-1991

### 2026-09-24: United States cancer deaths decreased by 35% since 1991

The AACR Cancer Progress Report 2026 reveals that cancer deaths in the US fell by 35% between 1991 and 2024, driven by improved prevention, early diagnosis, and new therapeutic technologies.

6 sources. https://clstr.news/cluster/united-states-cancer-deaths-decreased-by-35-since-1991

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Cite as: US cancer mortality rate trends. CLSTR, https://clstr.news/situations/us-cancer-mortality-rate-trends