# Zebrafish 3D seizure imaging with adaptive light‑sheet

> Live situation record from CLSTR: https://clstr.news/situations/zebrafish-3d-seizure-imaging-with-adaptive-lightsheet
> Updated: 2026-07-29T07:00:33.000Z. Sources: 5. Developments: 2.

Researchers at the University of Georgia reported the development of an adaptive light‑sheet microscopy platform capable of real‑time, three‑dimensional brain imaging during seizures. The initial description highlighted the system’s electrically tunable lens, sensorless adaptive optics, and ability to acquire volumes of up to 499 × 499 × 150 µm at four volumes per second, enabling observation of seizure onset in larval zebrafish and comparison between normal and gad1b‑mutant fish.

A week later the team announced the capture of the first continuous 3‑D footage of an epileptic seizure in a zebrafish larva. The upgraded setup reduced exposure, improved optical correction, and recorded a full volume in roughly 0.25 seconds—seven times faster than earlier versions—producing 600 uninterrupted 3‑D frames over two and a half minutes. The imaging revealed seizure activity beginning in the hindbrain and propagating forward, further elucidating the role of the gad1b gene in seizure dynamics.

## Timeline

### 2026-07-29: University of Georgia team captures first 3‑D footage of epileptic seizure in zebrafish brain

Georgia researchers use rapid light‑sheet microscopy to film 3‑D seizure spread in zebrafish brains, revealing propagation patterns and gene involvement, a step toward better epilepsy therapies.

2 sources. https://clstr.news/cluster/university-of-georgia-researchers-image-epilepsy-spread-in-zebrafish-brain

### 2026-07-21: University of Georgia team builds adaptive light-sheet microscope for 3D seizure imaging

University of Georgia scientists built an adaptive light-sheet microscope that records 3D brain seizures in zebrafish at high speed, revealing propagation patterns and gene effects.

3 sources. https://clstr.news/cluster/university-of-georgia-team-builds-adaptive-light-sheet-microscope-for-3d-seizure-imaging

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Cite as: Zebrafish 3D seizure imaging with adaptive light‑sheet. CLSTR, https://clstr.news/situations/zebrafish-3d-seizure-imaging-with-adaptive-lightsheet