Amorepacific develops microbiome solution for acne-related hyperpigmentation

Amorepacific has confirmed the potential of its proprietary microbiome strain, Bacillus velezensis AmoreLumina, to improve post-inflammatory hyperpigmentation (PIH) caused by acne. The research findings were published in the August online edition of the International Journal of Molecular Sciences.

Unlike traditional pigmentation management technologies that focus solely on inhibiting melanin synthesis, Amorepacific’s approach addresses both the prevention of new pigment and the removal of existing pigment. The study found that the AmoreLumina culture extract, which is rich in the natural functional substance Moranoline, inhibits the expression of melanin-producing enzymes. Simultaneously, it activates autophagy and lysosomal degradation pathways in macrophages that have already absorbed melanin.

This dual-action mechanism allows for the inhibition of new pigment formation while promoting the breakdown of residual pigment. Ex-vivo studies using human skin tissue demonstrated a significant reduction in hyperpigmentation induced by acne-causing bacteria and UV rays after treatment with the extract.