Arizona Cardinals face multiple injury setbacks ahead of season

The Arizona Cardinals are facing significant roster challenges due to injuries as they finalize their 53-man squad. Running back James Conner is set to begin the season on injured reserve with a designated return, meaning he will miss at least the first four games while rehabbing a foot and ankle injury. Running back Trey Benson is also on injured reserve and is expected to be out for the season.

The team's defensive secondary is also impacted. Cornerback Will Johnson is managing a lower body injury, and Garrett Williams is currently in a ramp-up period following an Achilles injury; his availability for Week 1 remains uncertain. To address depth, the Cardinals have been working with Denzel Burke and safety Dadrion Taylor-Demerson in nickel roles.