Artificial sweeteners linked to higher insulin and cardiometabolic risk in US study

A meta‑analysis of 21 randomized clinical trials by researchers at the Food is Medicine Institute, Tufts University, found that consumption of non‑nutritive sweeteners raised fasting insulin and HbA1c levels and showed a trend toward reduced insulin sensitivity. The analysis, published in *Current Atherosclerosis Reports*, also highlighted evidence that some sweeteners alter gut microbiota composition and function, which may contribute to a higher risk of cardiometabolic diseases.

The investigators noted limitations, including potential selection bias for participants already at risk of metabolic disorders, and cautioned that while these sweeteners can help reduce added sugar intake, their long‑term safety remains uncertain. They called for more research and suggested that, where possible, consumers limit use of high‑intensity sweeteners until clearer evidence is available.