Boston University researchers identify lung vein cells that drive fibrosis

Researchers at the Boston University Chobanian & Avedisian School of Medicine have identified a specific population of cells within the lung veins that actively drive the development of pulmonary fibrosis. Previously, blood vessels were thought to be passive bystanders in the scarring process, but this study suggests that specialized cells lining the lung vasculature become active following an injury, creating an environment that promotes scar tissue formation.

By using genetically engineered models and advanced laboratory techniques, the research team identified a previously unrecognized signaling pathway involved in this process. The study indicates that targeting this pathway could lead to new therapies designed to prevent or slow the progression of pulmonary fibrosis and other chronic fibrotic lung diseases. Initial testing with a drug that blocks the overactive signaling pathway showed potential in preventing lung scarring.