Brain regions found more vulnerable to dementia with Lewy bodies

A study published in the Journal of Biomedical Science suggests that brain tissue loss in dementia with Lewy bodies is not random, but preferentially affects specific regions with shared biological characteristics.

Led by Shady Rahayel of the Université de Montréal, an international research team compared MRI scans of 83 individuals with the condition to 86 healthy individuals. The findings revealed significant cortical thinning in the posterior regions of the brain, specifically the parietal, temporal, and occipital lobes.

Further analysis linked these affected areas to higher transcription of certain genes, particularly those related to mitochondrial function and synaptic communication. This research, conducted in collaboration with institutions in Canada, the UK, and the US, may help identify new therapeutic targets for the disease.