Buffalo Bills host New England Patriots in Week 4 AFC East matchup

The Buffalo Bills (3-0) are set to host the New England Patriots (1-2) in an AFC East matchup at Highmark Stadium. The Bills face significant defensive injury concerns, most notably with star cornerback Christian Benford listed as questionable due to a toe injury. Defensive lineman T.J. Sanders is also listed as doubtful due to illness.

The Patriots enter the game following a heavy loss to the Jacksonville Jaguars. Quarterback Drake Maye, who has struggled with six interceptions through three games, is dealing with a right shoulder issue but has practiced fully. New England will also be without cornerbacks Christian Gonzalez and Christian Barmore due to shoulder injuries.

Offensively, the Bills' receiving corps appears stable, with D.J. Moore and Keon Coleman expected to play despite limited practice participation. The Patriots' season has been marked by off-field distractions involving head coach Mike Vrabel, which some analysts suggest has impacted the team's performance.