Los Angeles Rams to host Buffalo Bills in Week 5 Monday Night Football

The Los Angeles Rams (2-2) will host the Buffalo Bills (3-1) at SoFi Stadium on Monday, October 12, 2026, for a Week 5 matchup. The game features a clash between two former MVP quarterbacks, Matthew Stafford and Josh Allen.

For the Rams, defensive end Aaron Donald has been cleared to return from a back injury after participating fully in practice. Other players expected to return include tight end Colby Parkinson and cornerback Jaylen Watson, while safety Quentin Lake remains questionable. Rams head coach Sean McVay noted that defensive end Myles Garrett is progressing from knee surgery but is unlikely to return next week.

The Buffalo Bills face significant injury challenges, with defensive tackle Ed Oliver and wide receiver Joshua Palmer ruled out. Wide receiver DJ Moore is listed as questionable due to a shoulder injury. Additionally, cornerback Dee Alford and defensive lineman Landon Jackson are also questionable.

Ahead of the game, Buffalo quarterback Josh Allen praised Rams head coach Sean McVay, describing him as one of the league’s best play-callers.