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[HEALTH] · South Korea, Austria · 4 sources

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Bundang CHA Hospital develops AI model to predict liver cancer immunotherapy effectiveness

AI medical model liver cancer treatment immunotherapy prediction CAPTYN hepatocellular carcinoma

A research team from Bundang CHA Hospital, in collaboration with medical professionals from the University of Vienna, has developed ‘CAPTYN’, an artificial intelligence-based model designed to predict the effectiveness of immunotherapy for liver cancer patients. The model specifically targets the combination therapy of atezolizumab and bevacizumab, which is a primary systemic treatment for advanced hepatocellular carcinoma (HCC).

CAPTYN utilizes machine learning to analyze six standard blood test indicators: C-reactive protein (CRP), alpha-fetoprotein (AFP), platelet count, total bilirubin, lymphocyte count, and neutrophil count. These markers reflect inflammation, tumor status, liver function, and immune status.

The model's performance was validated using data from 737 patients, including participants from the global phase 3 ‘IMbrave150’ clinical trial and real-world patient data from Severance Hospital. In external validation, CAPTYN achieved an Area Under the Curve (AUC) of 0.70 in the IMbrave150 trial, demonstrating superior predictive performance compared to existing models like CRAFITY and ALBI. The research, which highlights the potential for personalized treatment strategies in liver cancer, has been published in the journal Cancer Communications.

Entities

Bundang CHA Hospital · Cancer Communications · Hwang So-hyun · Jeon Hong-jae · University of Vienna

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Sources

면역항암제 간암치료 효과 예측 AI 모델 개발 - 의학신문 [www.bosa.co.kr]
분당차병원 교수팀, 면역항암제의 간암치료 효과 예측하는 AI 모델 개발 - 메디칼허브 [www.healthmedia.co.kr]
분당차병원 “6개 혈액검사지표, 면역항암제 간암치료 효과예측 AI 모델 개발” [www.thebionews.net]
혈액검사 6개로 간암 면역항암제 효과 예측…AI 모델 개발 [www.bokuennews.com]