Cellular senescence identified as therapeutic target for age-related diseases

cellular senescence SASP inflammaging DNA damage therapeutic targets

Medical experts from the Therapeutic Clinic of Alexandra Hospital and the National and Kapodistrian University of Athens are identifying cellular senescence as a key therapeutic target for age-related diseases. Cellular senescence is a state of permanent cell cycle arrest triggered by factors such as telomere shortening, DNA damage, oxidative stress, and epigenetic changes.

While this mechanism initially serves a protective role by preventing the proliferation of damaged cells and suppressing cancer, problems arise when these senescent cells accumulate in tissues. These cells remain biologically active and release a specific set of substances known as the Senescence-Associated Secretory Phenotype (SASP). This includes cytokines, chemokines, and enzymes that degrade the extracellular matrix.

The accumulation of SASP leads to a state of chronic, low-grade inflammation referred to as inflammaging, which is closely linked to various age-related pathologies and organ dysfunction.

Entities

Alexandra Hospital · Maria Kaparelou · National and Kapodistrian University of Athens · Thanos Dimopoulos · Theodorá Psaltopoulou

Claims

What the coverage asserts, and how many sources carry each claim.

[● 3 SOURCES] Cellular senescence is a stable arrest of the cell cycle. virus.com.gr · www.iatronet.gr · www.tanea.gr
[● 3 SOURCES] Senescent cells release cytokines, chemokines, and enzymes that degrade the extracellular matrix. virus.com.gr · www.iatronet.gr · www.tanea.gr
[● 3 SOURCES] Cellular senescence initially serves a protective function by preventing the multiplication of damaged cells and suppressing carcinogenesis. virus.com.gr · www.iatronet.gr · www.tanea.gr
[● 3 SOURCES] The Senescence-Associated Secretory Phenotype (SASP) creates an environment of chronic, low-grade inflammation known as inflammaging. virus.com.gr · www.iatronet.gr · www.tanea.gr
[● 3 SOURCES] Cellular senescence can be triggered by telomere shortening, persistent DNA damage, oxidative stress, or oncogene activation. virus.com.gr · www.iatronet.gr · www.tanea.gr