Chronic stress linked to cancer progression and heart disease

Researchers from the Cancer Research Center at the Tehran University of Medical Sciences have examined how chronic stress may influence the biology of cancer. A new review article suggests that long-term stress can affect various stages of the disease, including tumor growth, metastasis to other organs, and recurrence after treatment. This process is driven by the activation of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis, which release hormones such as adrenaline, noradrenaline, and cortisol. These hormonal changes can alter immune function, inflammation, and cellular metabolism, potentially creating an environment conducive to tumor behavior.

Additionally, medical experts emphasize that excessive stress is a significant risk factor for cardiovascular health. Chronic stress can exacerbate existing heart conditions and increase the risk of heart attacks and strokes. The physiological response to stress—including increased blood pressure, higher platelet levels, and reduced blood flow to the heart—can lead to blood clotting and arterial narrowing. Symptoms associated with chronic stress-related mental health issues include heart palpitations, arrhythmia, chest pain, and increased blood pressure.