CNIO research links intermittent fasting to delayed liver tumors

Researchers at the Spanish National Cancer Research Centre (CNIO) have found that intermittent fasting and caloric restriction can delay the appearance of liver tumors in mouse models. The study, led by Alejo Efeyan, head of the Metabolism and Cellular Signaling Group, examines how these nutritional interventions influence liver metabolism and tumor development.

The research evaluates two specific methods: a 30 percent reduction in daily food intake and an intermittent fasting protocol that limits feeding to a seven hour window each day. Both interventions were shown to favorably condition liver metabolism and slow tumor onset.

Because liver cancer is closely linked to obesity and metabolic alterations, scientists are focusing on the mTOR gene pathway, which regulates whether cells store fat or recycle energy. The ultimate goal of the project, which is supported by 1.25 million euros from the CRIS Against Cancer Program, is to develop precision medicine and drugs that can mimic the metabolic benefits of fasting without requiring patients to undergo hunger.