Creatine Supplement Shows Promise for Depression Therapy

Researchers from the University of Toronto and the University of Ottawa reviewed existing clinical trials and found that creatine monohydrate may improve outcomes for patients with depression, especially when taken alongside antidepressants or psychotherapy. The supplement appears to boost brain energy production by replenishing ATP and may influence dopamine and serotonin pathways, though the current evidence is insufficient for broad clinical recommendations.

Creatine is also widely used as a sports supplement to increase strength, muscle mass, and training intensity. The most studied and safest form is creatine monohydrate, which has extensive evidence supporting its performance‑enhancing benefits. While its potential mental‑health effects are being explored, creatine remains primarily known for its role in athletic performance.