Buffalo Bills host Detroit Lions in Highmark Stadium opener

The Buffalo Bills will host the Detroit Lions in a Week 2 primetime matchup on Thursday, September 17, marking the first regular-season game at the Bills’ new $2.1 billion Highmark Stadium. Both teams enter the contest with 1-0 records following narrow victories in Week 1.

The Lions narrowly defeated the New Orleans Saints 31-30 in overtime. Detroit faces significant injury concerns heading into Buffalo, with starting offensive linemen Christian Mahogany and Blake Miller officially ruled out. Cornerback D.J. Reed is also listed as questionable.

The Bills secured a 36-31 win over the Houston Texans in their opener. Buffalo’s injury report includes questionable designations for safety Cole Bishop, linebacker Terrel Bernard, and defensive lineman T.J. Sanders, while several other players have been cleared to play. The matchup features high-powered offenses led by quarterbacks Josh Allen and Jared Goff.