Diabetes research: Gene editing fails to stop cell rejection as AI targets misdiagnosis

Type 1 diabetes gene editing CRISPR-Cas9 beta cell transplantation medical misdiagnosis

Researchers at Koç University have investigated using CRISPR-Cas9 gene-editing technology to protect transplanted pancreatic beta cells from immune rejection in Type 1 diabetes patients. The study focused on disabling the RNLS and HIVEP2 genes to create beta-cell spheroids more resistant to autoimmune destruction. While disabling HIVEP2 did not significantly impact cell function, the loss of RNLS caused a modest reduction in insulin secretion in mouse cells. Ultimately, the single-gene edits were insufficient to prevent immune rejection in immunocompetent mice.

In a separate development regarding diabetes management, Breakthrough T1D and IQVIA have utilized artificial intelligence to address the frequent misdiagnosis of Type 1 diabetes as Type 2 diabetes in adults. Research indicates that up to 20 percent of Type 1 patients are misdiagnosed. The AI algorithm identified specific trends in misdiagnosed individuals, noting they were typically younger, weighed less, were less likely to have obesity or high blood pressure, and were more likely to be Caucasian.

Entities

Breakthrough T1D · IQVIA · Koç University

Claims

What the coverage asserts, and how many sources carry each claim.

[● 2 SOURCES] Single-gene edits failed to prevent immune rejection of transplanted beta cells in mice. www.azolifesciences.com · www.newswise.com
[○ 1 SOURCE] Breakthrough T1D and IQVIA developed an AI algorithm to help distinguish Type 1 diabetes from Type 2 diabetes in adults. www.breakthrought1d.org
[● 2 SOURCES] Researchers from Koç University investigated using gene editing to protect transplanted beta cells from immune attack. www.azolifesciences.com · www.newswise.com
[○ 1 SOURCE] Adults misdiagnosed with Type 2 instead of Type 1 diabetes were typically younger, weighed less, and were more likely to be Caucasian. www.breakthrought1d.org
[● 2 SOURCES] Researchers used CRISPR-Cas9 to disable the RNLS and HIVEP2 genes in mouse and human beta-cell lines. www.azolifesciences.com · www.newswise.com
[○ 1 SOURCE] Up to 20 percent of people with Type 1 diabetes are misdiagnosed with Type 2 diabetes. www.breakthrought1d.org

Sources

Single-Gene Edits Fall Short of Stopping Immune Rejection in Beta Cell Grafts [www.azolifesciences.com]

22 days ago

A New Tool to Accurately Diagnose Type 1 in Adults - Breakthrough T1D [www.breakthrought1d.org]

22 days ago

Single-Gene Edits Fail to Protect Transplanted Insulin-Producing Cells [www.newswise.com]

23 days ago