Dietary therapy and lifestyle changes emphasized for MASLD and MASH management

Medical experts emphasize that dietary therapy and lifestyle modifications serve as the foundation for managing Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction Associated Steatohepatitis (MASH), regardless of a patient's fibrosis stage or the use of pharmacological treatments.

Key clinical recommendations include adopting a Mediterranean-style diet and aiming for a weight loss of 7% to 10%. Physical activity, combining both resistance and aerobic exercise, is also considered essential. Experts note that a single consultation with a dietitian is often insufficient; instead, ongoing support and serial dietary sessions are necessary to ensure long-term adherence and compliance.

In addition to lifestyle changes, clinicians discussed monitoring alcohol consumption using PEth testing to avoid confounding treatment-response assessments. For patients undergoing medical therapies such as resmetirom or semaglutide, experts suggest using consistent imaging platforms to assess progress, with specific follow-up intervals recommended to monitor efficacy.