Feline genetic study reveals similarities to human cancer

An international genetic study involving nearly 500 domestic cats has identified significant similarities between feline and human cancers. Published in the journal Science, the research provides the first large-scale mapping of the domestic cat ‘cancer genome.’

Researchers from institutions including the Wellcome Sanger Institute, the University of Guelph’s Ontario Veterinary College, and the University of Bern found that many genes contributing to tumor development in cats are shared with or similar to those in humans. A notable finding involved aggressive breast tumors, where mutations in the FBXW7 gene—which regulates cell growth and division—were identified in over 50% of the examined cases. This same mutation is linked to human breast cancer and poor prognosis.

Beyond breast cancer, genetic similarities were found in tumors affecting the blood, bones, lungs, skin, gastrointestinal system, and central nervous system. Scientists noted that because cats live in similar environments to humans, they are exposed to comparable pollutants and chemicals, making them valuable models for studying how genetics and environment interact to trigger disease.