HBO's 'Life, Larry and the Pursuit of Unhappiness' features Kaley Cuoco and posthumous guest Rob Reiner

Kaley Cuoco guest‑stars in the second episode of HBO’s sketch‑comedy series Life, Larry and the Pursuit of Unhappiness. She appears as Gloria in a Great‑Depression‑era sketch and says, “I had no idea what the premise was,” noting she trusted Larry David and agreed without knowing the setting.

In the same episode, Rob Reiner makes a posthumous appearance as George Washington, delivering a speech that condemns political parties and references recent U.S. events such as the Jan 6 insurrection. Reiner’s Washington ends the sketch with the line, “We’re fucked.” Both sketches blend period comedy with contemporary political commentary and air Fridays at 9 p.m. ET on HBO and HBO Max.