High-fat diets linked to retinal damage and systemic inflammation

Research from Tianjin Medical University indicates that high-fat diets contribute to more than just obesity; they can also cause direct damage to the retina. A 15-week study on mice revealed that excessive fat intake leads to retinal inflammation and endothelial dysfunction. Specifically, the study identified the enzyme ECE-1 and the peptide ET-1 as key mediators. High levels of ET-1 cause blood vessels in the eye to narrow, reducing blood flow to the retina, a process closely linked to increased blood cholesterol.

Separately, medical experts highlight the distinct dangers of visceral fat compared to subcutaneous fat. While subcutaneous fat serves as an energy reserve, visceral fat—which accumulates around organs like the liver, pancreas, and kidneys—functions similarly to an endocrine organ. This fat remains in a state of chronic inflammation, releasing substances that increase the risk of cardiovascular disease and type 2 diabetes.