Hormonal changes and nutrition impact health during menopause

Research from Georgetown University’s Lombardi Comprehensive Cancer Center suggests that the hormone estrone may play a role in increasing the risk and aggressiveness of certain breast cancers after menopause. While estradiol is the primary estrogen before menopause, estrone becomes more dominant afterward, often produced through processes involving fat tissue. Studies indicate that estrone may promote inflammation and activate genes that support tumor development, whereas estradiol can reduce certain inflammatory signals.

Concurrently, nutritional management is highlighted as a key factor in navigating the physiological changes of menopause. Declining estrogen levels can lead to accelerated bone loss and increased abdominal fat storage. Experts suggest that a Mediterranean-style eating pattern—rich in vegetables, fruits, whole grains, lean proteins, and unsaturated fats—can help preserve muscle and bone density, support cardiovascular health, and manage metabolic function during the transition.