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Human microbiome and its role in daily health

The human microbiome consists of the collective genomes of trillions of microorganisms, including bacteria, viruses, fungi, and archaea, inhabiting the body. While the microbiota refers to the actual community of organisms, the microbiome represents their genetic heritage and the functions they perform.

These microbial communities, primarily located in the gut, skin, and mouth, play critical roles in digestion, immunity, metabolism, and mood regulation. In the intestines, microbial genes significantly outnumber human genes, enabling functions such as the digestion of complex fibers and the production of short-chain fatty acids like butyrate, propionate, and acetate.

Research from the Human Microbiome Project has identified over 10,000 microbial species in the human body. Beyond digestion, the microbiome influences gynecological health, fertility, and mental health. Maintaining a state of eubiosis, or microbial balance, is essential for health, whereas dysbiosis can lead to various diseases.

Entities

Human Microbiome Project · National Institutes of Health