IMBB researchers identify genetic mechanisms for mosquito insecticide resistance

Researchers at the Institute of Molecular Biology and Biotechnology (IMBB) of the Foundation for Research and Technology (FORTH) have identified the genetic mechanisms that allow mosquitoes to develop high levels of resistance to insecticides. The study, led by Dr. Linda Gregarakis and doctoral candidate Mengling Chen, was published in the Proceedings of the National Academy of Sciences (PNAS).

Using genetic engineering techniques, the team examined various resistance mechanisms, including mutations in the molecular targets of insecticides and the production of enzymes that break down these substances. This development poses a significant threat to public health, as mosquitoes are primary vectors for diseases such as malaria, dengue fever, and the West Nile virus.

While the use of modern insecticides has helped reduce malaria cases significantly since 2000, widespread application has led to increased resistance. Experts warn that the climate crisis may further exacerbate these risks by facilitating the spread of invasive mosquito species and extending their breeding seasons.