Immune system and genetics linked to extreme longevity

Recent scientific research suggests that longevity may be linked to specific immune system characteristics and genetic inheritance. Studies on centenarians indicate that a higher abundance of CD4 cytotoxic T cells—which are typically found in low quantities—may help the body maintain its ability to adapt to threats even at advanced ages.

Furthermore, an analysis of data from over 4,000 participants in the United States and the United Kingdom found that individuals with at least one parent who lived to be 100 years old experienced significant health advantages. These offspring showed a 42% lower risk of death, a 33% lower risk of cardiovascular disease, and a 32% lower risk of hypertension compared to those with shorter-lived parents.

The study noted that the onset of hypertension was delayed by approximately five years on average in these individuals. These findings remained consistent even after accounting for lifestyle factors such as smoking, diet, physical activity, and socioeconomic status, suggesting a strong biological component to extreme longevity.