Inrae researchers identify neurological mechanism to block tick salivation

Researchers in France, led by Inrae in collaboration with Anses, the École nationale vétérinaire d'Alfort, and the University of Orléans, have identified the neurological mechanism that controls salivation in the Ixodes ricinus tick. This species is a primary vector for diseases such as Lyme disease in Europe.

The study, published in Nature Communications, reveals that the tick's nervous system manages salivary glands through two distinct signaling pathways: one for continuous fluid secretion and another for producing the protein cocktail necessary for blood meals. By testing 37 substances, the team identified compounds capable of blocking these receptors. One specific compound targets invertebrates without affecting humans, offering potential for new repellents, gels, or patches that prevent disease transmission by stopping salivation.

Concurrently, veterinary experts warn that tick activity remains high during autumn. While many pet owners reduce preventative treatments after summer, the mild temperatures (between 7 and 15 degrees Celsius) and increased humidity of autumn create ideal conditions for ticks. The combination of moisture and dense vegetation makes the fall season a significant period of risk for domestic animals.