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Fondazione Nibit researchers identify mechanism for melanoma immunotherapy resistance
Researchers from Fondazione Nibit have identified a biological mechanism that allows certain metastatic melanoma cells to evade the immune system. Published in Science Advances, the study reveals that non-responsive cells change their identity, regressing to an immature, highly plastic state to survive immunotherapy attacks.
The study, known as Nibit-M4, involved 19 patients treated with a sequence of the epigenetic drug guadecitabine followed by the immunotherapy ipilimumab. While long-term results showed approximately 29% of patients remained alive five years after starting treatment, researchers sought to understand why some patients failed to respond.
Analysis showed that resistant cells tend to cluster in compact areas at the center of the tumor mass, creating a protective geometric structure that stabilizes their behavior. The research identified the protein NFATC2 as a potential key target to prevent such immunotherapy resistance.
Entities
Fondazione NIBIT · Michele Maio · NFATC2 · NFATC2 protein · Science Advances · University of Miami · University of Siena · guadecitabine · ipilimumab
Claims
What the coverage asserts, and how many sources carry each claim.
- [● 4 SOURCES] The protein NFATC2 has been identified as a potential target to prevent immunotherapy resistance. www.brontolodicelasua.it · www.insalutenews.it · www.terranostranews.it · www.gazzettadisiena.it
- [● 24 SOURCES] Non-responsive melanoma cells changed identity, regressing to an immature and plastic state to survive immune attacks. www.codirp.it · www.forchecaudine.com · notiziedi.it · www.lospecialegiornale.it · www.inliberta.it · +19 more
- [● 24 SOURCES] The study tested a combination of the epigenetic drug guadecitabine and the immunotherapy ipilimumab on 19 patients. www.adnkronos.com · www.brontolodicelasua.it · www.codirp.it · www.forchecaudine.com · notiziedi.it · +19 more
- [● 24 SOURCES] Researchers identified the biological mechanism used by some metastatic melanoma cells to evade the immune system. www.adnkronos.com · www.brontolodicelasua.it · www.codirp.it · www.forchecaudine.com · notiziedi.it · +19 more
- [○ 1 SOURCE] Approximately 29% of patients in the study remained alive five years after starting treatment. www.terranostranews.it
- [● 20 SOURCES] Resistant cells were found grouped in compact areas at the center of the tumor mass, creating a protective geometric structure. www.codirp.it · www.forchecaudine.com · notiziedi.it · www.lospecialegiornale.it · www.inliberta.it · +15 more