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Japan hospital performs first surgery using iPS heart muscle sheets
Surgeons at Osaka Keisatsu Hospital in Japan have performed the world's first clinical surgery using commercially available heart muscle stem cell sheets to treat severe heart failure. The procedure, which lasted approximately one hour, involved transplanting three sheets of cardiomyocytes derived from induced pluripotent stem (iPS) cells into a woman in her 50s.
The therapy, known commercially as RiHeart and developed by the startup Cuorips Inc., follows conditional government approval granted in March. The technology was created through a collaboration between surgeon Yoshiki Sawa and Nobel laureate Shinya Yamanaka. The iPS cells are reprogrammed from adult cells, allowing for tissue regeneration without the use of embryos.
This medical advancement aims to provide an alternative for patients with ischemic heart disease who have exhausted other treatment options, such as heart transplants or artificial hearts. Previous clinical trials involving eight patients showed symptom reduction in all participants. The medical team plans to conduct similar operations on 75 patients by 2033 to further evaluate the treatment's efficacy and safety for full authorization.
Entities
Cuorips Inc. · Japan · Osaka Keisatsu Hospital · Shinya Yamanaka · Yoshiki Sawa
Claims
What the coverage asserts, and how many sources carry each claim.
- [● 2 SOURCES] Surgeon Yoshiki Sawa expressed hope that the procedure will improve the patient's quality of life. www.myrepublica.nagariknetwork.com · www.japantimes.co.jp
- [● 2 SOURCES] The therapy, commercially known as RiHeart, was developed by the startup Cuorips Inc. japonsamourai.fr · www.upday.com
- [● 3 SOURCES] Clinical trials involving eight patients with ischemic heart disease showed all eight experienced symptom reduction. japonsamourai.fr · www.myrepublica.nagariknetwork.com · www.japantimes.co.jp
- [● 3 SOURCES] Osaka Keisatsu Hospital performed the world's first surgery using commercially available heart muscle stem cell sheets. japonsamourai.fr · www.myrepublica.nagariknetwork.com · www.japantimes.co.jp
- [● 2 SOURCES] The medical team plans to perform similar operations on 75 patients by 2033. www.myrepublica.nagariknetwork.com · www.japantimes.co.jp
- [● 2 SOURCES] The Japanese government granted conditional approval for this regenerative therapy in March. www.myrepublica.nagariknetwork.com · www.japantimes.co.jp
- [● 2 SOURCES] The technology was developed in collaboration with Nobel laureate Shinya Yamanaka. www.myrepublica.nagariknetwork.com · www.japantimes.co.jp
- [○ 1 SOURCE] The treatment costs 53.2 million yen per patient. japonsamourai.fr